Brisket Grilled Cheese

Ready in just 8 minutes, this smoky and rich brisket grilled cheese is perfect for when you crave something satisfying yet simple to prepare.

Brisket Grilled Cheese

Step by Step Video Instructions


Sourdough Bread: This bread’s robust texture is perfect for holding the hearty fillings. If you prefer a different type, a dense whole wheat bread can also work well.

Cheddar Cheese: Known for its excellent melting properties, cheddar cheese adds a creamy, gooey texture that perfectly complements the brisket.

Brisket: Opt for thick slices from the brisket’s point for maximum flavor and juiciness. This recipe is also a fantastic way to repurpose leftover brisket.

Mayonnaise: Use full-fat mayo to create a richer, more indulgent spread. It adds a creamy texture that enhances the overall flavor of the sandwich.

Barbecue Sauce: A smoky barbecue sauce can add an extra layer of depth to the sandwich, but feel free to use your favorite variety. The barbecue sauce brings a sweet and tangy element that complements the richness of the brisket and mayo.

Butter: Necessary for toasting the bread to a golden, crispy finish. For a dairy-free option, olive oil or a plant-based butter substitute can be used.

Expert Tips

Temperature: Keep the heat at medium to medium-low when toasting the sandwich. This allows the bread to achieve a golden-brown crispness without burning while giving the cheese ample time to melt thoroughly.

Using a Sandwich Press in the Skillet: For an extra crispy and evenly cooked sandwich, use a sandwich press while grilling in the skillet. Place the press on top of the sandwich as it cooks. This technique ensures even pressure and heat distribution, mimicking a panini press effect and leading to a perfectly toasted exterior and gooey cheese.

Selecting the Right Brisket Cut: For your sandwich, opt for slices from the point end of the brisket. This part is more marbled with fat, making it juicier and more flavorful.

Storage and Leftovers

While brisket grilled cheese sandwiches are undoubtedly best enjoyed fresh, if you’ve batch-cooked them or find yourself with leftovers, here’s how to best preserve and reheat them:

Cooling Before Storing: Allow your leftover sandwiches to cool to room temperature. This step helps prevent condensation inside the storage container, which can make the bread soggy.

Wrapping for Freshness: Once cooled, wrap each sandwich individually in aluminum foil. This helps retain the moisture in the brisket and cheese, keeping the sandwich more flavorful.

Reheating Method: The best way to reheat your brisket grilled cheese is in a sandwich press or in a skillet. This method warms the sandwich throughout and restores the crispiness to the bread. Heat the sandwich until it’s hot all the way through and the cheese begins to melt again.

Avoiding the Microwave: It’s best to avoid reheating these sandwiches in the microwave, as it can make the bread chewy and the cheese overly runny.


What’s the best cheese to use for melting?

American cheddar cheese is a great choice for its excellent melting properties. It provides a nice, gooey texture without overpowering the brisket. Other good melting cheeses include Gouda and Provolone.

Can I prepare Brisket Grilled Cheese sandwiches ahead of time?

Yes, you can prepare these sandwiches in advance by assembling them without heating. Store the assembled sandwiches in the refrigerator, and then cook them in a skillet or sandwich press when you’re ready to serve.

Where’s the best place to buy brisket?

The best place to buy brisket often depends on your location and preference for meat quality. Generally, local butchers, meat markets or even bbq restaurants offer excellent sources for high-quality brisket. Additionally, many grocery stores carry brisket, especially larger chains with well-stocked meat departments. If neither of these are available there are also many online specialty food stores or online meat suppliers which are great places to look.

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Brisket Grilled Cheese

Brisket Grilled Cheese

Ready in just 8 minutes this smoky and rich brisket grilled cheese is perfect for when you crave something satisfying yet simple to prepare.
5 from 1 vote
Prep Time 2 minutes
Cook Time 6 minutes
Total Time 8 minutes
Course Main Dish
Cuisine American
Servings 1
Calories 651 kcal


  • 1 Skillet


  • 2 Slices Sourdough Bread
  • 2 Slices Cheddar Cheese
  • 2 Slices Brisket Nice thick slices from the point
  • 1 Tbsp Mayonnaise
  • 1 Tbsp Barbecue Sauce
  • 1 tsp Butter


  • In a small bowl, combine 1 tablespoon of mayonnaise with 1 tablespoon of barbecue sauce. Mix them well and then set the bowl aside.
  • Place a large skillet over medium heat to warm up. Add the brisket slices to the skillet, heating them for about 1 to 2 minutes on each side or until they’re thoroughly heated through.
  • Take your sourdough bread slices and spread the prepared mayo-bbq sauce mixture on the inside of each slice.
  • On one slice of bread, lay the warmed brisket slices. Place the cheddar cheese slices on top of the brisket, then close the sandwich with the other slice of bread, sauce side down.
  • Add a small amount of butter to the skillet (now set at a medium-low heat). Once the butter has melted, place your sandwich in the skillet.
  • Toast the sandwich for about 1 to 2 minutes on each side. You’re aiming for a golden-brown crust on the bread and a lovely melt to the cheese.
  • Once the sandwich is perfectly toasted, remove it from the skillet. Slice it in half and serve immediately.


Calories: 651kcalCarbohydrates: 72gProtein: 24gFat: 29gSaturated Fat: 11gPolyunsaturated Fat: 8gMonounsaturated Fat: 6gTrans Fat: 0.2gCholesterol: 52mgSodium: 1296mgPotassium: 227mgFiber: 3gSugar: 12gVitamin A: 514IUVitamin C: 0.1mgCalcium: 315mgIron: 5mg
Keyword Brisket Grilled Cheese
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